Strategies for oocyte rejuvenation: to what extent?

Infertility attributed to male and female factors affects millions of couples worldwide. Although assisted
reproductive technologies (ART) can circumvent some of these fertility problems, the efficacy of the treatments is greatly dependent on the quality of the oocytes used. Frequently, oocytes from patients of advanced age or with other fertility disorders (e.g, polycystic ovarian syndrome, endometriosis) fail to fertilize, produce embryos that arrest during the first stages of their development in vitro or develop into chromosomally abnormal blastocysts. The use of donated oocytes can represent an effective approach to
improve the chances of successful IVF treatment in these patients, however, the resultant children are not genetically related to the intended mothers and thus it desirable to develop other alternatives

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