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A second baby was born through the application of the maternal spindle transfer technique in the context of the clinical research project that is being carried out by Embryotools and the Institute of Life in Greece. In the framework of this clinical research pilot trial, the effectiveness and safety of the maternal spindle transfer technique is being investigated as a means to treat infertility problems associated to cytoplasmic dysfunctions in oocytes – which manifest by a “massive” embryo development arrest in IVF cycles with conventional techniques – as well as to prevent the transmission of mitochondrial diseases.

The infant was born at 07:00 am on November 11^th, 2019, to a Greek women with a long history of IVF failures with conventional techniques. Both the mother and the infant are well. The birth of the first baby through maternal spindle transfer in the context of this specific clinical research study had taken place last April 2019. The infant is now seven months old, is being follow-up, and is in an excellent condition. All results of this research project that is expected to be concluded within the next months will be made public after the acceptance of the publications in specialized peer-reviewed journals.

About the maternal spindle transfer Project

The maternal spindle transfer method involves the replacement of the entire cytoplasm of oocytes, fully preserving the nuclear genome of the woman who wants to reproduce. The proof of principle of the procedure has been extensively explored in animal models and pre-clinically validated with human oocytes donated for research.  Currently, the technique is being applied in a very restrict and carefully selected cohort of patients in the context of an ongoing research protocol that was approved and is being conducted in accordance with the terms and conditions of the Greek Law 3305/2005. Based on current scientific data, the maternal spindle transfer method is still considered an experimental technique and is not an established infertility treatment nor a recognized method of medically assisted reproduction.

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Researchers from the Spanish centre Embryotools —with headquarters in the Barcelona Science Park (Parc Científic de Barcelona, PCB) — are participating in a landmark scientific event in Greece that will shape the future of assisted reproduction. In a pilot clinical trial conducted on women, which is being sponsored by the assisted reproduction centre Institute of Life in Athens, Spanish scientists have achieved the world’s first pregnancy that uses the Maternal Spindle Transfer technique to solve problems of infertility.

 

Pregnancy reported in the first trial of ‘three-person IVF’ for infertility – STAT – statnews.com A 32-year-old Greek woman is reportedly pregnant from an experimental reproductive technique that uses DNA from three people — as part of the first known clinical trial to use the controversial … www.statnews.com

 

MIT Tech Review: ｢3人の親｣を持つ子、欧州で紡錘体移植による不妊治療が実施 ニューズライン エマージング・テクノロジーの最新情報をお届け。 Another use of an egg-swapping IVF technique has just been reported in Europe ｢3人の親｣を持つ子、欧州で紡錘体移植による不妊治療が実施 www.technologyreview.jp

 

Embryotools achieves the world’s first pregnancy with a new nuclear transfer technique for treating infertility – Parc Científic de Barcelona www.pcb.ub.edu

 

Logran un embarazo con una nueva técnica pionera en el mundo para infertilidad – lavanguardia.com Investigadores de Barcelona y Atenas (Grecia) han logrado un embarazo en una mujer con problemas de infertilidad a la que se ha aplicado la técnica de Transferencia de Huso Materno (MST, en sus … www.lavanguardia.com

 

Una mujer con problemas de fertilidad logra quedarse embarazada gracias a una avanzada técnica | ANTENA 3 TV Investigadores de Barcelona y Atenas. Una mujer con problemas de fertilidad logra quedarse embarazada gracias a una avanzada técnica. Este es el primer embarazo registrado en el mundo con una … www.antena3.com

Embryotools和Microptic 之间的合作开始于我们实验室进行精子分析，并提供CASA系统培训（计算机辅助精液分析）。

我们知道，男科学是辅助生殖科的一个非常重要的专业。 更具体地说，如果我们专注于精液的分析，应用适当的方案，就有可能得出男性不育的诊断结果，从而能够提供治疗。 另一方面，在IVF-ICSI治疗之前，精子测试总是有帮助的。

Microptic专门从事精液分析已有20多年历史，是拥有SCA – 精子分析仪®的CASA系统的先驱企业之一。 此外，该公司已经向该行业的专业人士和经销商提供了不同层次的培训和实践研讨会。

与手工分析不同，由于分析标准化和结果记录，CASA系统提高了实验室的竞争力。

CASA SCA系统，由Microptic

由于这种用于分析精子样本的自动测量软件，可以按照WHO标准分析以下参数：

Embryotools is currently involved in several research projects that aim to develop new technologies for the treatment of infertility problems.

Among them we highlight the project financed by the European Reginal Development funds (ERDF) Ref. RD 15-1-0011 that aims to develop a new technique for meiotic spindle replacement in oocytes affected by mitochondrial or other cytoplasmic problems.

Project title: Desenvolupament d’una novedosa tècnica de TRA: transferència de fus matern (MST). RD 15-1-0011.

Maternal spindle transfer overcomes embryo developmental arrest caused by ooplasmic defects in mice

Fourth Baby Born in 14 Months Using the Maternal Spindle Transfer Method as Part of Pilot Trial Conducted by the Institute of Life and Embryotools Scientific Team

董事

Gloria Calderón, PhD

董事长

西班牙IVF之母，作为主要人员参与完成西班牙第一例试管婴儿。 • 在IVF科学领域逾30年的经验，擅长的专业领域包括临床胚胎学、实验室质控、和实验室设计等方面。 • 自2000年担任西班牙IVI集团（逾2.5万周期/年）首席科学顾问及实验室代表。 • 担任西班牙6所大学的硕士生导师。 • 自1991年开始应邀到全球IVF中心进行指导，包括西班牙、英国、法国、比利时、希腊、巴西、阿根廷、墨西哥、土耳其、智利、秘鲁等。 • 曾受邀到欧洲、美洲、亚洲、中东等30多个国家的生殖会议和研讨会（包括ESHRE等）担任讲师 • 在Human Reproduction, Fertility and Sterility, EHSRE, ASRM等国际会议及知名生殖杂志发表超过200多篇论文和摘要 • Human Reproductive Medicine 复核委员会成员

Nuno Costa-Borges, PhD

科学总监

参与完成西班牙第一例动物克隆 • 参与完成欧洲首例应用PiezoDrill的马匹胚胎活检 • 担任Eppendorf胚胎显微操作的独立科学顾问 • 在临床胚胎学和IVF实验室质控方面拥有丰富经验 • 受邀担任葡萄牙里斯本Champalimaud Foundation癌症研究中心讲师 • 同行审阅杂志发表多篇文章和摘要，包括：Human Reproduction; Reproduction; Cellular Reprogramming; Cloning and Stem Cells; Theriogenology; Reproduction Fertility and Development等. • 曾在ESHRE, AETE, ASEBIR发表大量口述交流和科学壁报 • 获西班牙、波兰、德国的科学组织颁授奖项 • 操流利葡萄牙语、英语、西班牙语和加泰罗尼亚语。

General management

实验室工作人员

Enric Mestres, PhD

胚胎

实验室经理

Mònica Acacio, MSc

胚胎

Alba Casals

实验室技术员

Andrea Villamar

实验室技术员

Queralt Matia, MSc

实验室技术员

Carolina Castelló, BSc

胚胎

Albert Martínez, MSc

实验室技术员

行政

外部科学顾问

Dagan Wells, PhD

Scientific Advisor

Dagan Wells has been actively involved in preimplantation genetic diagnosis (PGD) and the study of human gametes and embryos for over two decades, conducting his first PGD cases in 1992. He spent several years developing novel PGD tests at University College London, accomplishing the first comprehensive chromosome analysis of cells from human embryos in 1998, using a combination of whole genome amplification and comparative genomic hybridisation (CGH). In 1999 Dagan moved to the United States and joined Reprogenetics, one of the world’s largest providers of PGD services. In 2003 he initiated Reprogenetics’ highly successful single gene PGD program, testing embryos for numerous serious inherited conditions. Dagan later joined the faculty of Yale University Medical School, where he spent four years running a research laboratory, before returning to the UK in late 2007. His research group is now located in the Nuffield Department of Obstetrics and Gynaecology at the University of Oxford. Dagan’s work has led to the publication of more than 120 peer-review publications and book chapters and has been recognized with the award of numerous prizes and grants. He is a Fellow of the Royal College of Pathologists and currently serves on the Editorial Boards of several international journals. Dagan also directs Reprogenetics-UK, an independent laboratory offering state-of-the-art PGD services to IVF clinics throughout the UK and internationally.

Klaus Wiemer, PhD

Scientific Advisor

Dr. Klaus Wiemer has an extensive clinical and scientific background and experience in cell and embryo culture, cryopreservation of embryos, embryo morphology and assessment, co-culture, blastocyst development, IVF lab design, and supervision. He has extensive experience in all aspects of clinical embryology. He received his doctorate in Reproductive Physiology (Embryology) in 1989 from Louisiana State University, Baton Rouge, LA, USA. Dr Wiemer has over 20 years of experience directing IVF Laboratories and has been involved in over 10,000 IVF procedures. He was the Scientific Director of the Institute for Assisted Reproduction, Charlotte, NC, USA for 10 years, and Laboratory Director for NorthWest Center for Reproductive Sciences, Kirkland, WA, USA for 7 years. He currently directs several embryology laboratories and is a founding partner in the newly formed Poma Fertility Center. Dr Wiemer has published over 75 peer-reviewed articles and book chapters on a wide range of topics in the area of clinical embryology. His main interests are in embryo culture systems, improving laboratory outcomes and studying the effects of follicular stimulations on subsequent oocyte and embryo quality. He is currently conducting research on developing an embryo morphology grading system that can be used to predict rate and quality of blastocyst development. Other projects include various aspects of oocyte as well as blastocyst vitrification systems.

Klaus Rink, PhD

Scientific Advisor

German physicist, specialized in experimental physics, fluent in English and French. He is renowned for research and development of laser products for medical applications in the fields of in vitro fertilization, tissue welding and the treatment of kidney stones. In 2000 he co-founded OCTAX Microscience GmbH in Germany. OCTAX develops and manufactures IVF medical equipment, ranging from therapeutic to diagnostics appliances. OCTAX is reputed worldwide for producing the most reliable and accurate laser equipment, researched and developed by Dr. Rink since 1992. Scientific achievements: /1st birth after laser assisted hatching (1.48 μm) /1st birth after laser assisted blastomere biopsy and PGD /1st birth after laser assisted polar body biopsy /1st birth after laser assisted immobilization of spermatozoa /1st pregnancy after laser assisted zona drilling for ICSI /1st pregnancy after laser assisted removal of necrotic blastomeres from cryopreserved embryos

Etienne Van den Abbeel, PhD

Scientific Advisor

Etienne Van den Abbeel obtained his MSc in Chemical Engineering in 1974. In 1983 he moved to the reproductive biology research group of the Dutch-speaking Free University to work with Professor Andre Van Steirteghem. His research focused on cryobiology and cryopreservation, optimizing gamete and embryo selection and in vitro culture. Etienne Van den Abbeel was a principal investigator and copromotor of several research projects granted by the Belgian government (FWO and IWT) . In 1987 he became a Senior Clinical Embryologist and expert research scientist at the Centre for Reproductive Medicine of the University Hospital of the Dutch-speaking Brussels CRM which was directed by Professor Andre Van Steirteghem and Professor Paul Devroey. The Brussels CRM, famous for its landmark research in reproductive medicine became one of the most successful in vitro fertilization (IVF) units worldwide. In 2006, at the Brussels Free University, he defended succesfully a thesis to become PhD in Medical Sciences. He obtained the ESHRE Certificate of Senior Clinical Embryologist in 2008. In 2010 he moved to the Centre of Reproductive Medicine of the University Hospital of Gent, Belgium and took the position of IVF Laboratory Director. He also holds the title of Professor in Clinical Embryology at the University of Ghent. His research topics continued to be on cryobiology and cryopreservation, culture and selection of mammalian gametes and embryos. Etienne Van den Abbeel has authored or co-authored over 80 peer reviewed papers and chapters in books. Etienne Van den Abbeel has been more than 200 times an invited lecturer and presented some 250 accepted oral and poster communications at scientific meetings and seminars. He is a reviewer for 15 different scientific journals. He is currently also a member of several national and international professional organisations, a past coordinator of the European Society for Human Reproduction and Embryology (ESHRE) Special Interest Group in Embryology and from 2009 till 2013 has been a member of the Executive Committee of ESHRE .

Business Advisor