{"id":20952,"date":"2020-07-06T18:46:08","date_gmt":"2020-07-06T16:46:08","guid":{"rendered":"https:\/\/embryotools.com\/?p=20952"},"modified":"2020-07-06T18:49:54","modified_gmt":"2020-07-06T16:49:54","slug":"maternal-spindle-transfer-overcomes-embryo-developmental-arrest-caused-by-ooplasmic-defects-in-mice","status":"publish","type":"post","link":"https:\/\/embryotools.com\/fr\/maternal-spindle-transfer-overcomes-embryo-developmental-arrest-caused-by-ooplasmic-defects-in-mice\/","title":{"rendered":"Maternal spindle transfer overcomes embryo developmental arrest caused by ooplasmic defects in mice"},"content":{"rendered":"<p class=\"qtranxs-available-languages-message qtranxs-available-languages-message-fr\">D\u00e9sol\u00e9, cet article est seulement disponible en <a href=\"https:\/\/embryotools.com\/en\/wp-json\/wp\/v2\/posts\/20952\" class=\"qtranxs-available-language-link qtranxs-available-language-link-en\" title=\"English\">English<\/a> et <a href=\"https:\/\/embryotools.com\/es\/wp-json\/wp\/v2\/posts\/20952\" class=\"qtranxs-available-language-link qtranxs-available-language-link-es\" title=\"Espa\u00f1ol\">Espa\u00f1ol<\/a>. Pour le confort de l\u2019utilisateur, le contenu est affich\u00e9 ci-dessous dans la langue par d\u00e9faut du site. Vous pouvez cliquer l\u2019un des liens pour changer la langue du site en une autre langue disponible.<\/p><p><\/p>\n<header class=\"article-section__header\">\n<h2 class=\"article-section__header_text\">Abstract<\/h2>\n<\/header>\n<div class=\"article-section__body\">\n<p class=\"paragraph\">The developmental potential of early embryos is mainly dictated by the quality of the oocyte. Here, we explore the utility of the maternal spindle transfer (MST) technique as a reproductive approach to enhance oocyte developmental competence. Our proof-of-concept experiments show that replacement of the entire cytoplasm of oocytes from a sensitive mouse strain overcomes massive embryo developmental arrest characteristic of non-manipulated oocytes. Genetic analysis confirmed minimal carryover of mtDNA following MST. Resulting mice showed low heteroplasmy levels in multiple organs at adult age, normal histology and fertility. Mice were followed for five generations (F5), revealing that heteroplasmy was reduced in F2 mice and was undetectable in the subsequent generations. This pre-clinical model demonstrates the high efficiency and potential of the MST technique, not only to prevent the transmission of mtDNA mutations, but also as a new potential treatment for patients with certain forms of infertility refractory to current clinical strategies.<\/p>\n<\/div>\n<p><a href=\"https:\/\/elifesciences.org\/articles\/48591?utm_source=content_alert&amp;utm_medium=email&amp;utm_content=fulltext&amp;utm_campaign=1-June-20-elife-alert\" target=\"_blank\" rel=\"noopener noreferrer\">Read more<\/a><\/p>","protected":false},"excerpt":{"rendered":"<p>D\u00e9sol\u00e9, cet article est seulement disponible en English et Espa\u00f1ol. Pour le confort de l\u2019utilisateur, le contenu est affich\u00e9 ci-dessous dans la langue par d\u00e9faut du site. Vous pouvez cliquer l\u2019un des liens pour changer la langue du site en une autre langue disponible. Abstract The developmental potential of early embryos is mainly dictated by\u2026<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[173,1],"tags":[],"class_list":["post-20952","post","type-post","status-publish","format-standard","hentry","category-in-the-news","category-various"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Maternal spindle transfer overcomes embryo developmental arrest caused by ooplasmic defects in mice - Embryotools<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/embryotools.com\/fr\/maternal-spindle-transfer-overcomes-embryo-developmental-arrest-caused-by-ooplasmic-defects-in-mice\/\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:title\" content=\"Maternal spindle transfer overcomes embryo developmental arrest caused by ooplasmic defects in mice - Embryotools\" \/>\n<meta name=\"twitter:description\" content=\"D\u00e9sol\u00e9, cet article est seulement disponible en English et Espa\u00f1ol. 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Abstract The developmental potential of early embryos is mainly dictated by\u2026\" \/>\n<meta name=\"twitter:creator\" content=\"@embryotools\" \/>\n<meta name=\"twitter:site\" content=\"@embryotools\" \/>\n<meta name=\"twitter:label1\" content=\"\u00c9crit par\" \/>\n\t<meta name=\"twitter:data1\" content=\"Web master\" \/>\n\t<meta name=\"twitter:label2\" content=\"Dur\u00e9e de lecture estim\u00e9e\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/embryotools.com\\\/fr\\\/maternal-spindle-transfer-overcomes-embryo-developmental-arrest-caused-by-ooplasmic-defects-in-mice\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/embryotools.com\\\/fr\\\/maternal-spindle-transfer-overcomes-embryo-developmental-arrest-caused-by-ooplasmic-defects-in-mice\\\/\"},\"author\":{\"name\":\"Web master\",\"@id\":\"https:\\\/\\\/embryotools.com\\\/#\\\/schema\\\/person\\\/fa5c8bd04e7fd28a48cb3358051f2ec3\"},\"headline\":\"Maternal spindle transfer overcomes embryo developmental arrest caused by ooplasmic defects in mice\",\"datePublished\":\"2020-07-06T16:46:08+00:00\",\"dateModified\":\"2020-07-06T16:49:54+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/embryotools.com\\\/fr\\\/maternal-spindle-transfer-overcomes-embryo-developmental-arrest-caused-by-ooplasmic-defects-in-mice\\\/\"},\"wordCount\":338,\"publisher\":{\"@id\":\"https:\\\/\\\/embryotools.com\\\/#organization\"},\"articleSection\":[\"Nouvelles\",\"Various\"],\"inLanguage\":\"fr-FR\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/embryotools.com\\\/fr\\\/maternal-spindle-transfer-overcomes-embryo-developmental-arrest-caused-by-ooplasmic-defects-in-mice\\\/\",\"url\":\"https:\\\/\\\/embryotools.com\\\/fr\\\/maternal-spindle-transfer-overcomes-embryo-developmental-arrest-caused-by-ooplasmic-defects-in-mice\\\/\",\"name\":\"Maternal spindle transfer overcomes embryo developmental arrest caused by ooplasmic defects in mice - 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Abstract The developmental potential of early embryos is mainly dictated by\u2026","twitter_creator":"@embryotools","twitter_site":"@embryotools","twitter_misc":{"\u00c9crit par":"Web master","Dur\u00e9e de lecture estim\u00e9e":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/embryotools.com\/fr\/maternal-spindle-transfer-overcomes-embryo-developmental-arrest-caused-by-ooplasmic-defects-in-mice\/#article","isPartOf":{"@id":"https:\/\/embryotools.com\/fr\/maternal-spindle-transfer-overcomes-embryo-developmental-arrest-caused-by-ooplasmic-defects-in-mice\/"},"author":{"name":"Web master","@id":"https:\/\/embryotools.com\/#\/schema\/person\/fa5c8bd04e7fd28a48cb3358051f2ec3"},"headline":"Maternal spindle transfer overcomes embryo developmental arrest caused by ooplasmic defects in mice","datePublished":"2020-07-06T16:46:08+00:00","dateModified":"2020-07-06T16:49:54+00:00","mainEntityOfPage":{"@id":"https:\/\/embryotools.com\/fr\/maternal-spindle-transfer-overcomes-embryo-developmental-arrest-caused-by-ooplasmic-defects-in-mice\/"},"wordCount":338,"publisher":{"@id":"https:\/\/embryotools.com\/#organization"},"articleSection":["Nouvelles","Various"],"inLanguage":"fr-FR"},{"@type":"WebPage","@id":"https:\/\/embryotools.com\/fr\/maternal-spindle-transfer-overcomes-embryo-developmental-arrest-caused-by-ooplasmic-defects-in-mice\/","url":"https:\/\/embryotools.com\/fr\/maternal-spindle-transfer-overcomes-embryo-developmental-arrest-caused-by-ooplasmic-defects-in-mice\/","name":"Maternal spindle transfer overcomes embryo developmental arrest caused by ooplasmic defects in mice - 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